In this review, we first briefly introduce the structural composition, host cell surface receptors and life cycle of RSV virions. Then, we discuss the latest findings related to the pathogenesis of RSV.

Apr 12, 2024 · Four new studies led by Harvard Medical School researchers at Boston Children’s Hospital reveal details about how B cells in the immune system churn out antibodies that become …

Beas-2B cell cultures were used to examine mechanisms regulating BAFF expression. Results BAFF protein and mRNA were elevated (in marked contrast with APRIL) in BAL and bronchial brushings, …

Jun 17, 2025 · This study explored its therapeutic potential and molecular mechanism in respiratory syncytial virus (RSV)-induced pediatric bronchiolitis (PB). BEAS-2B cells were infected with RSV …

In this review, we summarize the role of immunosuppressive Bregs in airway inflammatory diseases and highlight the importance of this subset in the maintenance of respiratory health.

May 1, 2024 · In our study, B cell depletion was achieved by administering α-CD20 three times every 5 days, starting 7 days before influenza A virus (IAV) infection, while IFN-β was given on days 1 and 2 …

May 30, 2025 · In light of the importance of RSV and related research developments, this narrative review summarizes the recent epidemiology, pathogenesis, clinical presentation, diagnosis, …

In recent years, advances in genome editing technologies and animal modeling have facilitated rapid progress in our ability to study eB cells and execute proof-of-concept studies, thus...

Jul 22, 2021 · To conclude, antibody-independent B cell functions seem to have an important role in regulating both acute and chronic viral infections and may form the basis for novel therapeutic …

Oct 10, 2024 · EDP-323, an investigational inhibitor of Respiratory Syncytial Virus (RSV), is showing promising results in Phase 2a trials. While other RSV therapies and vaccines are approved for …