Oct 30, 2025 · Conjugated bilirubin, also known as direct bilirubin, is a water-soluble form of bilirubin that has been processed by the liver. It is formed when unconjugated bilirubin undergoes a chemical …

Aug 29, 2025 · Unconjugated bilirubin is insoluble in water. This means it can only travel in the bloodstream if bound to albumin and it cannot be directly excreted from the body. In contrast, …

High or low bilirubin levels might indicate that some part of the process of breaking down and clearing old red blood cells isn’t working correctly. What do bilirubin levels in your blood indicate? Healthcare …

Jul 24, 2023 · With this conversion, the hydrophilic bilirubin glucuronide, or conjugated bilirubin, travels into the bile canaliculus via ATP binding cassette transporter, the multi-drug resistance protein 2 …

Sep 25, 2025 · Conversion of heme to bilirubin — Bilirubin is formed by breakdown of heme present in hemoglobin, myoglobin, cytochromes, catalase, peroxidase, and tryptophan pyrrolase.

Bilirubin metabolism occurs in a series of steps following hemoglobin breakdown and results in the excretion of conjugated bilirubin as waste products, stercobilin and urobilin.

Bilirubin must be conjugated before it can be excreted into bile (conjugation makes bilirubin water soluble, because it breaks apart the hydrogen bond within the molecule, which keep it hydrophobic …

Apr 29, 2025 · Conjugated hyperbilirubinemia occurs when bilirubin, a red blood cell by-product, builds up in the bloodstream after processing in the liver.

Conjugated hyperbilirubinemia is usually due to hepatocellular injury or cholestasis, intrahepatic or extrahepatic. Early diagnosis and management are carried out to prevent complications. Bilirubin is a …

Aug 11, 2025 · Once in the liver, this indirect bilirubin undergoes conjugation - a process where it's combined with glucuronic acid to become direct or conjugated bilirubin. This transformation makes …