Researchers at Arizona State University’s (ASU) School of Molecular Sciences and the Biodesign Institute’s Center for the Mechanism of Evolution have discovered an unprecedented pathway producing ...

New research from the University of Maryland and the National Institutes of Health reveals a new role for the enzyme telomerase. Telomerase's only known role in normal tissue was to protect certain ...

Telomerase contains a large RNA subunit, TER, and a protein catalytic subunit, TERT. Whether telomerase functions as a monomer or dimer has been a matter of debate. Here we report biochemical and ...

Of the many components in the cell thought to play a role in cancer, few have received more attention in recent years than an enzyme that has been dubbed a cellular fountain of youth. Known as ...

Biochemists have produced a three-dimensional structural model of telomerase's RNA "core domain." Telomerase is an enzyme that helps maintain telomere DNA -- the DNA found at the very ends of ...

MENLO PARK, Calif.--(BUSINESS WIRE)--Geron Corporation (Nasdaq:GERN) today announced the publication of preclinical data on TAT2, a small molecule telomerase activator. The studies show that human CD8 ...

Researchers have published the first detailed picture and description of the 3-dimensional molecular structure of telomerase – a discovery that could enable better targeted drug screening and could ...

In an effort to understand and control telomerase activity, researchers have discovered a protein "motif," named TFLY, which is crucial to the function of telomerase. Altering this motif disrupts ...

Telomeres are stabilized, and telomeric DNA is replenished, by the action of the ribonucleoprotein reverse transcriptase telomerase. Telomere capping functions include the ability of telomeres to ...

The stem terminus element (STE), which was discovered 13 y ago in human telomerase RNA, is required for telomerase activity, yet its mode of action is unknown. We report that the Schizosaccharomyces ...

Loss-of-function mutations in telomerase complex genes can cause bone marrow failure, dyskeratosis congenita, and acquired aplastic anemia, both diseases that predispose to acute myeloid leukemia.