BIRC7–E2 ubiquitin conjugate structure reveals the mechanism of ubiquitin transfer by a RING dimer
Post-translational modification by Ub is an important regulatory mechanism for a wide variety of cellular processes 1,2. Ub is activated and conjugated to substrate by the consecutive actions of a ...
More than 600 human genes encode RING or RING-like E3 ligases, underscoring their biological importance 1. Canonical RING proteins contain a zinc-binding region that is rich in cysteine and histidine ...
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