Cancer cells are characterized by a great potential to proliferate and evade apoptosis, as well as a capacity to develop blood vessels, invade tissues and metastasize (Hanahan and Weinberg, 2000).
Of note, the authors found that both TGF-β3 and TGF-β1 signal through the same receptor (TGF-βRII) for Th17 differentiation, suggesting that TGF-β3 and TGF-β1 deliver differential downstream signaling ...
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