The cytochromes P450 (CYPs) are the main enzyme family for metabolism of therapeutic drugs. CYP3A4 is the most active drug metabolizing CYP, and it plays a prominent role in adverse drug-drug ...
The substrate cocktail is frequently used to evaluate cytochrome P450 (CYP) enzyme-mediated drug interactions and potential interactions among the probe substrates. Here, we re-optimized the substrate ...
Proceedings of the National Academy of Sciences of the United States of America, Vol. 93, No. 10 (May 14, 1996), pp. 4644-4648 (5 pages) Among biological catalysts, cytochrome P450 is unmatched in its ...
The identification of phytoalexin biosynthetic genes would open the door to targeted breeding or metabolic engineering of these pathways for plant and human health. For example, the glucosinolate ...
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