Mid-Day

WHO strongly recommends CD4 testing to identify advanced HIV disease

At presentation, all children living with HIV younger than five years should be considered as having advanced HIV disease ...
The American Journal of Managed Care

CD4 T-cell and Lymphocyte Monitoring: Clinical Significance in HIV Treatment

A panelist discusses how CD4 counts serve as measures of immune system status that typically increase by about 200 in the first year of antiretroviral therapy. Although there can be laboratory ...
European Medical Journal

Lung Transplantation in People Living With HIV

A single center letter describes lung transplantation in people living with HIV despite CD4 counts under 200 during evaluation, emphasizing prior viral suppression and clinical context when assessing ...
Medscape

High Immune Activation in Patients With Undetectable Viral Loads and Low CD4-Cell Counts

The decrease in CD4 cells during HIV infection seems to be driven by immune activation, which does not always correlate with viral load. Experienced clinicians are all too familiar with the ...
Fred Hutch

HIV’s secret sweet tooth: T cell glycosylation determines variant entry

At the cellular level, HIV-1 transmission involves a highly coordinated process whereby the virus binds to CD4 receptors and one of two coreceptors—CCR5 (R5) or CXCR4 (X4)—on host immune cells, ...
Fred Hutch

Targeting B cells – a new approach to HIV treatment?

There are currently ~38 million people worldwide living with HIV. If left untreated, HIV infection progresses to acquired immunodeficiency syndrome (AIDS) where patients become extremely vulnerable to ...